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Target intelligence / Profile preview
Microtubule-associated protein tau (tau)
- Target
- tau
- Molecular classification
- Microtubule-associated protein
01
Overview
Microtubule-associated protein tau (tau) is a protein primarily found in neurons, where it stabilizes microtubules. It is encoded by the MAPT gene. Tau's function is regulated by phosphorylation, and its hyperphosphorylation and aggregation into neurofibrillary tangles are hallmarks of tauopathies, including Alzheimer's disease. Tau interacts with tubulin subunits to promote microtubule assembly and stability, which are essential for axonal transport and neuronal polarity. Targeting tau is a therapeutic strategy for neurodegenerative diseases.
- Other names
- MAPT
02
Mechanism of action
Modulation of tau phosphorylation and aggregation
03
Biological functions
Microtubule stabilizationRegulation of microtubule dynamicsAxonal transportNeuronal polaritymRNA Translation Regulation
04
Disease associations
Alzheimer's diseaseFrontotemporal dementiaProgressive supranuclear palsyTauopathiesNeurodegenerative disease
05
Safety considerations
Off-target effects due to widespread expressionPotential for exacerbating other neurodegenerative processesBlood-brain barrier penetration challenges
06
Biomarkers
Tau levels in cerebrospinal fluid (CSF)Tau levels in plasmaTau PET imaging
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