Microtubule-associated protein Tau–microtubule complex (Tau–microtubule complex (or Tau–MT complex))

The **Tau–microtubule complex** refers to the dynamic, non-covalent interaction between the microtubule-associated protein Tau and microtubules. Tau is crucial for maintaining microtubule stability, especially in neurons, where it regulates cytoskeletal integrity, axonal transport, and neuronal morphology[1][2][3][6][7]. Tau binds along microtubule protofilaments, primarily via its microtubule-binding region (MTBR; residues 242–367), stabilizing microtubules against depolymerization and promoting their assembly[2][3][5]. The affinity and mode of binding are regulated by alternative splicing (yielding Tau isoforms) and post-translational modifications, especially phosphorylation[5]. In disease conditions, such as Alzheimer’s disease and related tauopathies, abnormal phosphorylation of Tau reduces its microtubule binding, leading to Tau aggregation and neurofibrillary tangle formation, key pathological hallmarks[1][2][6]. --- **Target assessment and commentary**: - The term **“Microtubule–Tau complex”** is not considered a canonical therapeutic target; rather, its components (Tau and tubulin/microtubule) are individually targeted in therapy and research. Drug discovery efforts generally focus on Tau as a target for modulating its aggregation or phosphorylation, or on tubulin as a target in cancer chemotherapy. Therefore, this entry is **marked as incorrect as a target** (is_incorrect: true), although the molecular interaction is biologically critical[2][3][6]. - No approved or established drugs specifically target the complex as such. Antimitotic drugs (e.g., vinblastine) target microtubules, and investigational drugs target Tau, but not the interaction per se[1]. - The molecular classification is "Other," as this is a **protein–protein complex** rather than a receptor, enzyme, transporter, or ion channel. If you are seeking information about **“Tau protein”** or **“microtubule-associated protein Tau”** specifically, those are canonical and well-defined therapeutic targets—let me know if you require detailed data for either individual component.

Other names

Tau–microtubule interactionTau–MT complexTau–tubulin complex

Not applicable (see note below)