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Target intelligence / Profile preview
Microtubule-associated protein tau (Phosphorylated) (None specified)
- Target
- None specified
- Molecular classification
- Microtubule-associated protein, Phosphoprotein
01
Overview
Microtubule-associated protein tau (MAPT) is a neuronal protein that stabilizes microtubules and regulates axonal transport. Phosphorylation regulates tau's function; hyperphosphorylation leads to detachment from microtubules, aggregation into neurofibrillary tangles, and neurodegeneration in Alzheimer's disease and other tauopathies. Key phosphorylation sites include Ser199/Ser202/Thr205, Thr212, Thr231/Ser235, Ser262/Ser356, Ser396/Ser404, and Ser422. Kinases such as MARKs phosphorylate tau. Mutations can promote increased phosphorylation rates.
- Other names
- MAPT (Phosphorylated)Phosphorylated taup-tau
02
Mechanism of action
Kinase inhibition to reduce tau phosphorylation, promotion of microtubule stabilization, inhibition of tau aggregation.
03
Biological functions
Microtubule stabilizationAxonal transport regulationmRNA translation regulation (negative)
04
Disease associations
Alzheimer's diseaseTauopathiesNeurodegenerative diseaseFrontotemporal dementia
05
Safety considerations
Potential for off-target effects of kinase inhibitorsChallenges in selectively targeting pathologically phosphorylated tauBlood brain barrier penetration for drug delivery
06
Biomarkers
Phosphorylated tau levels in cerebrospinal fluid (CSF)Phosphorylated tau levels in plasmaPET imaging of tau aggregates
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