Microtubule-associated protein tau (phosphorylated at Ser413) (pS413 tau)

Microtubule-associated protein tau (MAPT) is a primary structural protein in neurons responsible for stabilizing microtubules and supporting axonal transport. In neurodegenerative conditions known as tauopathies, most notably Alzheimer's disease, tau undergoes aberrant post-translational modifications, including hyperphosphorylation, which causes it to detach from microtubules and aggregate into toxic oligomers and neurofibrillary tangles (NFTs). Phosphorylation at the serine 413 (pS413) residue has been identified as a specific and early marker of these pathological tau species, appearing before the formation of mature tangles. Therapeutic strategies targeting pS413 tau, such as the monoclonal antibody MK-2214, aim to intercept extracellular tau 'seeds' to halt the progressive spread of pathology throughout the brain. By neutralizing these toxic forms, these interventions seek to preserve synaptic function and slow the clinical progression of cognitive and functional decline in patients with early-stage Alzheimer's disease.

Other names

pS413 taup-tau413phosphorylated serine 413 taupSer413 tauPhospho-tau (Ser413)

Passive immunotherapy using monoclonal antibodies to selectively bind and neutralize extracellular pathological tau species phosphorylated at Ser413, thereby preventing the neuron-to-neuron spread (seeding) of tau aggregates and promoting their clearance.