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Microtubule-associated proteins (MAP)
- Target
- MAP
- Molecular classification
- Protein
01
Overview
Microtubule-associated proteins (MAPs) are a diverse group of proteins that interact with microtubules, regulating their stability, organization, and function. They are crucial for maintaining cell structure, facilitating intracellular transport, and mediating interactions between microtubules and other cellular components. MAPs can both stabilize and destabilize microtubules. They are divided into families such as MAP1, MAP2, MAP4, and Tau. Their binding is regulated by phosphorylation. Dysregulation or mutation of MAPs are implicated in neurodegenerative diseases.
- Other names
- MAPsType I MAPs (MAP1 family)Type II MAPs (MAP2 & MAP4)Tau protein
02
Mechanism of action
N/A
03
Biological functions
Regulate stability of microtubule polymersRegulate dynamics of microtubule polymersGuide spatial arrangement of microtubule networks within cellsMediate cross-linking between microtubules or with other cytoskeletal elementsRegulate intracellular transport
04
Disease associations
Neurodegenerative disease
05
Safety considerations
Dysregulation or mutation implicated in neurodegenerative diseases
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