Microtubule-associated scaffold protein 1 (MTUS1)

Microtubule-associated scaffold protein 1 (MTUS1) is a cytoskeletal scaffold and tumor suppressor protein encoded by the MTUS1 gene on human chromosome 8p22. MTUS1 generates multiple protein isoforms by alternative splicing, most notably the ATIP (Angiotensin II receptor-interacting protein) family, including ATIP1, ATIP2, ATIP3, and ATIP4. The protein is characterized by its C-terminal domain, which interacts with the angiotensin II receptor type 2 (AT2), and a large coiled-coil region for dimerization. MTUS1 is implicated in modulating microtubule stability, cell polarity, apoptosis, cell cycle, and signal transduction, particularly through its interaction with AT2 receptor pathways. Loss or mutation of MTUS1 is linked to various cancers, where it acts as a tumor suppressor, and it also plays a role in cardiac development and disease. Its downregulation can serve as a biomarker for several malignancies. While direct drug interactions are not currently reported, MTUS1 could be considered an indirect drug target due to its effect on angiogenesis and signal cascades via AT2R signaling[1][3][5][7].

Other names

Microtubule-associated tumor suppressor 1Mitochondrial tumor suppressor 1MTSG1Angiotensin II receptor-interacting protein (ATIP; with main isoforms ATIP1, ATIP2, ATIP3, ATIP4)ATBPKIAA1288GK1DKFZp586D1519FLJ14295ATIP1MP44ICISATIP3

Indirect: Modulation of AT2 (angiotensin II type 2) receptor signaling (MTUS1/ATIP isoforms interact with AT2 receptor and regulate downstream signaling such as inhibition of cell proliferation and promotion of apoptosis); Tumor suppressor pathways modulation