Microtubule-associated scaffold protein 2 (MTUS2)

Microtubule-associated scaffold protein 2 (MTUS2) is a cytoskeletal-associated protein involved in binding microtubules and protein homodimerization[1][4][6]. It localizes to the centrosome, cytoplasmic microtubule, intercellular bridge, and nucleus, and is implicated in regulating microtubule dynamics, particularly at the growing distal tips of microtubules[1][4][6]. MTUS2 interacts with proteins such as MAPRE1 and may target the microtubule depolymerase KIF2C, suggesting a functional role in controlling microtubule structure and dynamics during cell division and migration[6]. While annotated as a tumor suppressor candidate based on its name and some disease associations, its direct use as a therapeutic target is not established, and no drugs are listed as acting on this protein[1][2].

Other names

Microtubule-associated tumor suppressor candidate 2CAZIPKIAA0774TIP150Tracking protein of 150 kDaICISCardiac zipper proteinMicrotubule plus-end tracking protein TIP150+TIP of 150 kDa