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Microtubule dynamics protein
- Molecular classification
- Protein, Enzyme, Motor protein, Microtubule-associated protein (MAP), Other
01
Overview
Microtubule dynamics proteins are a diverse class of proteins that regulate the assembly, disassembly, and function of microtubules within cells. Their activity is critical for cell division, intracellular transport, cell signaling, and migration. Dysregulation of these proteins is implicated in cancer and other diseases, making them important therapeutic targets. Clinically, drugs acting on microtubule dynamics proteins disrupt mitosis and are widely used in cancer therapy, but their broad cellular functions present challenges for selectivity and safety.
- Other names
- Microtubule-associated protein (MAP)Microtubule motor protein (includes kinesin, dynein, etc.)Microtubule binding proteinMicrotubule plus-end tracking protein (+TIP)Microtubule stabilizer/destabilizer
02
Mechanism of action
Inhibition of microtubule polymerization (vinca alkaloids, colchicine-site drugs); Stabilization of microtubules (taxanes, epothilones); Promotion of microtubule degradation (PROTACs, experimental approaches)
03
Biological functions
Cell cycle regulation (mitosis, spindle formation)Intracellular transport (organelle trafficking)Cell migration and polaritySignal transductionApoptosisCell proliferationCell death
04
Disease associations
Cancer (major role as drug targets in chemotherapy; overexpression/mutation linked to tumor progression)Neurodegenerative disease (tau protein in Alzheimer’s)Other (various cell division disorders, developmental defects)
05
Safety considerations
Neurotoxicity (peripheral neuropathy is a major side effect)Resistance mechanisms (alterations in tubulin or MAP expression)Myelosuppression
06
Interacting drugs
Taxanes (paclitaxel, docetaxel)
5 more in the full profile.
07
Biomarkers
Beta-III tubulin isoform (predicts response to agents like ixabepilone)MAPT (tau protein, cytoskeletal integrity)Stathmin (correlates with cancer prognosis)
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