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Microtubule Plus End (MT +end)
- Target
- MT +end
- Molecular classification
- Cytoskeletal component, Polymer of tubulin dimers
01
Overview
The microtubule plus end is one of the two distinct ends of a microtubule, characterized by exposed β-tubulin subunits. It exhibits dynamic instability, alternating between phases of growth, pause, and shrinkage. The plus end is crucial for various cellular processes, including cell division, motility, and intracellular transport, and is regulated by plus-end tracking proteins (+TIPs) like EB1/EB3 and CLIP170. Disruption of plus-end dynamics is implicated in diseases like cancer and neurodevelopmental disorders. Microtubule plus ends are a target for cancer therapy.
- Other names
- Microtubule growing endMicrotubule distal tip
02
Mechanism of action
Taxanes stabilize microtubules, preventing depolymerization. Colchicine and vinca alkaloids bind to tubulin dimers and prevent polymerization.
03
Biological functions
Microtubule polymerizationIntracellular transportCell divisionCell motilityCell morphogenesisOrganelle positioningChromosome segregation
04
Disease associations
CancerNeurodevelopmental disordersNeurodegenerative disorders
05
Safety considerations
NeurotoxicityMyelosuppressionDrug resistance
06
Interacting drugs
Taxanes (e.g., Paclitaxel, Docetaxel)
2 more in the full profile.
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