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Target intelligence / Profile preview
Microtubule Polymer (MT)
- Target
- MT
- Molecular classification
- Cytoskeletal protein, Polymer
01
Overview
Microtubules are dynamic, cylindrical polymers composed of α- and β-tubulin heterodimers. They are a fundamental component of the eukaryotic cytoskeleton, providing structural support, determining cell shape, and facilitating various cellular processes such as intracellular transport, cell division (mitosis), and motility. Microtubule assembly occurs via a nucleation–elongation mechanism involving reversible, non-covalent addition of tubulin dimers at both ends. GTP hydrolysis on β-tubulin drives dynamic instability. Microtubules are major targets in cancer therapy due to their critical role in mitosis.
02
Mechanism of action
Modulating microtubule stability/dynamics
03
Biological functions
Cell shape/supportIntracellular transportMitosis/spindle formationCell motilityChromosome segregation
04
Disease associations
Cancer
05
Interacting drugs
Vinca alkaloids (vinblastine)
3 more in the full profile.
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