Target intelligence / Profile preview

Tubulin Polymerization (Microtubule) (N/A)

Target: N/A
Molecular classification: Protein complex, Polymerization process

Overview

Tubulin polymerization is the process by which α-tubulin and β-tubulin protein subunits assemble into microtubules, a key component of the eukaryotic cytoskeleton. Microtubules are dynamic, hollow cylindrical structures crucial for cell shape, intracellular transport, chromosome segregation, and cell motility. The dynamics of tubulin polymerization are a major target for anticancer drugs, with agents either stabilizing or destabilizing microtubules to disrupt cell division.

Other names: Microtubule AssemblyTubulin AssemblyMicrotubule PolymerizationTubulin-microtubule cycle

Mechanism of action

Stabilizing agents promote tubulin polymerization/stabilize existing microtubules, preventing depolymerization. Destabilizing agents inhibit tubulin polymerization/destabilize existing microtubule structure, disrupting formation/functionality of spindles.

Biological functions

Cell shape maintenanceIntracellular transportOrganelle positioningChromosome segregationCell motilityMitotic spindle formation

Disease associations

CancerNeurodegenerative diseases (indirectly)Other (diseases associated with cilia/flagella dysfunction)

Safety considerations

Peripheral neuropathy (vinca alkaloids, taxanes)MyelosuppressionDrug resistanceOff-target effects on normal microtubule function

Interacting drugs

Paclitaxel

6 more in the full profile.

Biomarkers

Expression levels of tubulin isotypesTumor sensitivity/resistance to tubulin-targeting agents (e.g., through gene expression profiling)

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