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Target intelligence / Profile preview
Microtubule Polymerization Proteins (N/A)
- Target
- N/A
- Molecular classification
- Structural protein, Microtubule-associated protein, Motor protein, Kinase, Phosphatase
01
Overview
Microtubule polymerization proteins are a diverse group of proteins that regulate the assembly and dynamics of microtubules, which are cytoskeletal polymers essential for cell shape, intracellular transport, mitosis, and other cellular processes. These proteins include structural components (such as tubulin subunits) and regulatory factors (such as microtubule-associated proteins or MAPs). Microtubule polymerization dynamics are targeted in cancer therapy through microtubule-targeting agents that either stabilize or destabilize microtubules to disrupt mitosis in rapidly dividing cells.
- Other names
- Microtubule-associated proteins (MAPs)Tubulinγ-tubulin ring complex (γ-TuRC)
02
Mechanism of action
Targeted stabilization or destabilization of microtubules, disruption of mitotic spindle formation.
03
Biological functions
Microtubule polymerizationMitotic spindle formationIntracellular transportCell shape maintenanceCell motilityRegulation of microtubule dynamics
04
Disease associations
CancerNeurodegenerative disease (indirectly related through transport defects)
05
Safety considerations
NeurotoxicityMyelosuppressionDrug resistance
06
Interacting drugs
Paclitaxel
6 more in the full profile.
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