Target intelligence / Profile preview

Microtubule protein beta chain (β-tubulin)

Target
β-tubulin
Molecular classification
Structural protein, Cytoskeletal protein
01

Overview

The microtubule protein beta chain (β-tubulin) is an essential cytoskeletal component involved in maintaining cell shape, enabling intracellular transport processes, facilitating accurate chromosome segregation during cell division, and serving as a critical drug target—especially in oncology—for agents that modulate its polymerization dynamics.

Other names
Beta tubulin
02

Mechanism of action

Microtubule stabilization or destabilization, leading to mitotic arrest and apoptosis

03

Biological functions

Structural supportIntracellular transportMitosisMeiosisCell motilityCell shape maintenanceOrganelle positioning
04

Disease associations

CancerNeurodegenerative disease
05

Safety considerations

Drug resistanceNeurotoxicityMyelosuppression
06

Interacting drugs

Paclitaxel

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