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Target intelligence / Profile preview
Microtubule Protein Tubulin (N/A)
- Target
- N/A
- Molecular classification
- Structural protein, Cytoskeletal protein, GTPase
01
Overview
Tubulin is a highly conserved globular protein that forms the building block of microtubules, essential components of the eukaryotic cytoskeleton. It exists as α/β heterodimers that polymerize to form protofilaments, which then assemble into microtubules. Tubulin plays vital roles in structural support, intracellular transport, cell division, and cilia/flagella formation. Dysregulation or mutations in tubulins are implicated in cancer and neurological disorders, making them important therapeutic targets.
- Other names
- Tubulinα-tubulinβ-tubulinγ-tubulinTUBATUBB
02
Mechanism of action
Taxanes stabilize microtubules, inhibiting cell division. Vinca alkaloids inhibit tubulin polymerization, disrupting microtubule formation and cell division.
03
Biological functions
Structural supportIntracellular transportCell divisionMitosisMeiosisCilia formationFlagella formationMitochondrial ion channel regulationChromatin remodelingDNA damage response
04
Disease associations
CancerNeurological disordersAlzheimer's diseaseTubinopathies
05
Safety considerations
Chemotherapy-related toxicitiesNeurological side effects
06
Interacting drugs
Taxanes
2 more in the full profile.
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