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Microtubule Protein Tubulin Alpha Chain Beta Chain Dimer (Tubulin α/β dimer)

Target: Tubulin α/β dimer
Molecular classification: Structural protein, Cytoskeletal protein

Overview

The tubulin alpha-beta dimer forms the basic unit from which all eukaryotic microtubules are built. Its dynamic assembly/disassembly underlies many vital cellular processes including cell division. Structural features—such as nucleotide binding sites—and diversity through isoforms/post-translational modifications make it central not only to normal physiology but also an important target for therapeutic intervention against diseases like cancer.

Other names: α/β-tubulin heterodimerTubulin dimerAlpha/beta tubulin dimer

Mechanism of action

Stabilization of microtubules (Taxanes) or inhibition of polymerization (Vinca alkaloids)

Biological functions

Microtubule assemblyCell divisionIntracellular transportStructural supportOrganelle positioningIntracellular signaling

Disease associations

CancerNeurodegenerative diseasesDevelopmental disordersMitochondrial dysfunction

Safety considerations

Drug resistanceNeurotoxicity (for some microtubule-targeting agents)Myelosuppression (for some microtubule-targeting agents)

Interacting drugs

Paclitaxel (Taxol)

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