Target intelligence / Profile preview

Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein (MERS-CoV Spike)

Target: MERS-CoV Spike
Molecular classification: Viral protein, Glycoprotein, Type I transmembrane protein

Overview

The MERS-CoV spike glycoprotein is an essential multifunctional envelope protein responsible for mediating virus-host cell interactions through its distinct domains. Its ability to bind human DPP4 determines infectivity and pathogenesis while also serving as a major antigenic determinant targeted by immune responses and therapeutic interventions.

Other names: MERS-CoV S proteinSpike glycoproteinS protein

Mechanism of action

Blocking receptor binding; Inhibiting membrane fusion

Biological functions

Viral entryReceptor bindingMembrane fusionHost cell attachment

Disease associations

InfectionMERS-CoV infectionRespiratory disease

Safety considerations

Potential for antibody-dependent enhancement (ADE)Elicitation of non-neutralizing antibodiesRisk of immune escape mutations

Interacting drugs

Neutralizing antibodies

2 more in the full profile.

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