Target intelligence / Profile preview

Midkine (MK)

Target: MK
Molecular classification: Growth Factor, Cytokine

Overview

Midkine (MK) is a heparin-binding growth factor and cytokine involved in development, tissue repair, and tumorigenesis. It promotes cell proliferation, migration, angiogenesis, and survival signaling. Overexpression is observed in various cancers, making it a potential therapeutic target. It interacts with multiple receptors including PTPζ, LRP1, integrins, ALK, and syndecans.

Other names: ARAPMDKMEKMK1MKARAPNEGF2Neurite growth-promoting factor 2

Mechanism of action

Inhibition of Midkine signaling via antibodies, small molecule inhibitors of its receptors (e.g., PTPζ inhibitors), or interfering with heparin binding.

Biological functions

Cell proliferationCell migrationAngiogenesisFibrinolysisSurvival signalingTissue repairImmune modulationNeurotrophic effects

Disease associations

CancerNeurodegenerative diseaseInflammationAutoimmune CNS disorders

Safety considerations

Potential for off-target effects due to widespread expression and pleiotropic functionsRisk of disrupting normal development if targeted during embryogenesisPossible immune-related adverse events with antibody-based therapies

Biomarkers

Midkine levels in serum/plasma as a diagnostic or prognostic marker in cancerMidkine expression in tumor tissue to predict response to therapy

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