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MIEF1 microprotein (MIEF1-MP)
- Target
- MIEF1-MP
- Molecular classification
- Other (mitochondrial microprotein, mitoribosome assembly factor)
01
Overview
MIEF1 microprotein (MIEF1-MP) is a 70-amino-acid mitochondrial microprotein encoded by a small upstream open reading frame in the 5′ UTR of the mitochondrial dynamics protein MID51 (MIEF1) gene. MIEF1-MP is conserved in vertebrates and has been detected in various human cell lines and tissues. It localizes to the mitochondrial matrix and associates with the mitoribosome, where it functions as a regulator of mitochondrial translation and may play a role in mitoribosome assembly. Knockdown of MIEF1-MP reduces mitochondrial protein synthesis, while overexpression increases it. No known drugs directly target this microprotein, and it is not classified as a common therapeutic target such as a receptor or enzyme[1][3].
- Other names
- MIURFAltMIEF1AltMiD51MIEF1MIEF1-MPmitochondrial ribosome and complex I assembly factor AltMIEF1MIEF1 microproteinalternative MIEF1 proteinalternative transcript upstream of MiD51
02
Biological functions
Regulation of mitochondrial translationMitoribosome association/assemblyPotential regulation of mitochondrial fission/fusion
03
Disease associations
Other (dysfunction in protein translation, possible mitochondrial disease risk factor—no direct established disease linkage)
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