MIF4G domain-containing protein (MIF4GD)

MIF4G domain-containing protein (MIF4GD), also known as SLIP1, is a non-canonical MIF4G-like adaptor protein involved in the translation and nuclear export of replication-dependent histone mRNAs, which lack the typical poly(A) tail and instead feature a stem-loop structure. MIF4GD interacts directly with the stem-loop binding protein (SLBP), facilitating efficient translation of histone mRNAs. The protein forms homodimers (and potentially heterodimers with similar factors such as CTIF), serving as a platform to bridge SLBP and other proteins involved in mRNA metabolism, such as eIF3g (a translation initiation factor) and DBP5 (an mRNA export factor). SLIP1 is essential for cell viability, presumably due to its central role in histone mRNA processing and translation, processes critical for S-phase progression and cell cycle regulation. The MIF4G domain is characterized by multiple alpha helical repeats and is structurally related to other translation factors[1][2][3][4]. No direct drugs, disease associations, clinical biomarkers, or major safety concerns are reported for this molecule itself in the provided literature.

Other names

MIF4GDSLIP1hSLIP1AD023MGC45027SLBP-interacting protein 1MIFD