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Minichromosome maintenance complex component 8 (MCM8)
- Target
- MCM8
- Molecular classification
- Enzyme, DNA helicase, Minichromosome maintenance (MCM) protein family
01
Overview
Minichromosome maintenance complex component 8 (MCM8) is an ATP-dependent DNA helicase that forms a functional complex with MCM9, known as the MCM8/9 complex. This complex plays an essential role in the initiation of DNA replication, progression and stabilization of replication forks, and repair of DNA double-strand breaks via homologous recombination. MCM8 is critical for genome integrity; its malfunction or overexpression is implicated in cancer development, tumor progression (such as in osteosarcoma), and infertility. MCM8 serves as a molecular motor regulating DNA metabolism in both normal and pathological contexts, with ongoing research into its potential as a therapeutic target and biomarker for cancer and genetic disorders[1][2][4][8].
- Other names
- DNA helicase MCM8Minichromosome maintenance 8 homologous recombination repair factor
02
Mechanism of action
Inhibition of helicase activity may block DNA replication and repair, leading to reduced cell proliferation and increased apoptosis in tumor cells[4].
03
Biological functions
DNA replication (initiation and fork progression)Homologous recombination repairMeiosisDNA repair (including repair of double-stranded breaks and interstrand crosslinks)Cell cycle regulation
04
Disease associations
CancerInfertilityTumor progression (e.g., osteosarcoma)
05
Safety considerations
Potential on-target toxicity related to impairing essential DNA repair and replication processes in healthy cellsInfertility risk due to effects on meiosis and genome stability[1]
06
Interacting drugs
null (No clinically approved drugs specifically targeting MCM8 are currently listed in the literature)
07
Biomarkers
Overexpression in cancer (potential diagnostic and prognostic biomarker)Expression levels in tumor tissues (e.g., osteosarcoma) may indicate disease progression and malignancy[4].
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