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Minichromosome maintenance domain-containing protein 2 (MCMDC2)
- Target
- MCMDC2
- Molecular classification
- Other (MCM-like protein; not a canonical enzyme, receptor, channel, or transporter)
01
Overview
Minichromosome maintenance domain-containing protein 2 (MCMDC2) is a protein from the MCM (minichromosome maintenance) family of DNA-associated factors that is essential for meiotic recombination and gametogenesis in mammals[1][2][3][4][6]. MCMDC2 is required for repairing programmed DNA double-strand breaks in meiosis, enabling proper homologous chromosome pairing, synapsis, and crossover formation[1][2][4][6]. Deficiency in MCMDC2 results in infertility in both sexes due to failed meiosis: males exhibit spermatogenic arrest, and females fail to form proper follicles[1][2][3][4]. Unlike canonical MCM complexes, MCMDC2’s function appears meiosis-specific and is not essential for mitotic DNA replication[2][4]. There are currently no known disease biomarker or pharmacological agents directly targeting MCMDC2, and no characterized safety concerns have been reported for its inhibition or modulation in a clinical context[3][6].
- Other names
- C8orf45FLJ25692MCM domain-containing protein 2MCM domain-containing protein C8orf45minichromosome maintenance domain-containing protein 2[3]
02
Biological functions
Meiotic recombination[1][2][4][6]Double-strand break DNA repair[1][2][3][4][6]Chromosome pairing and alignment in meiosis[2][4]Gametogenesis (oogenesis, spermatogenesis)[2][3]
03
Disease associations
Infertility (azoospermia and impaired oogenesis)[1][2][3]Other (potential but not established: tumorigenesis, e.g., retroperitoneal leiomyosarcoma association)[3]
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