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Target intelligence / Profile preview
Minor Histocompatibility Antigen 1 (None)
- Target
- None
- Molecular classification
- Antigen, Rho GTPase Activating Protein (RhoGAP)
01
Overview
Minor Histocompatibility Antigen 1 (HA-1) is a polymorphic peptide presented by MHC class I molecules, arising from the HMHA1 gene. HA-1 is selectively expressed on hematopoietic cells and some solid tumors. Mismatches between donor and recipient HA-1 alleles can lead to GVHD or graft-versus-leukemia effects after allogeneic hematopoietic stem cell transplantation. HA-1 is being explored as an immunotherapeutic target to enhance anti-leukemia effects and in vaccination strategies for metastatic cancers.
- Other names
- HA-1HMHA1
02
Mechanism of action
T-cell mediated killing of HA-1 expressing cells
03
Biological functions
Immune responseRegulation of actin cytoskeletonRho GTPase regulationCell spreadingCell migration
04
Disease associations
Graft-versus-host disease (GVHD)LeukemiaSolid tumorsCancer
05
Safety considerations
Graft-versus-host disease (GVHD)On-target, off-tumor toxicity
06
Biomarkers
HA-1 H/R allele statusHA-1 peptide presentation on MHC class I
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