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Target intelligence / Profile preview
Minor Histocompatibility Antigen HA-1 (HA-1)
- Target
- HA-1
- Molecular classification
- Minor histocompatibility antigen, Peptide presented by MHC class I
01
Overview
Minor histocompatibility antigen HA-1 is a polymorphic peptide presented by MHC class I molecules, primarily HLA-A*02:01. It is derived from the HMHA1 gene and plays a crucial role in immune responses following allogeneic hematopoietic stem cell transplantation. Mismatching for HA-1 can lead to graft-versus-host disease (GVHD), while also mediating beneficial graft-versus-leukemia (GVL) effects. Due to its restricted expression on hematopoietic cells, HA-1 represents a promising target for immunotherapeutic strategies against hematologic malignancies such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
- Other names
- mHag HA-1HMHA1
02
Mechanism of action
Vaccination to induce T cell response against HA-1 expressing cells. T-cell mediated cytotoxicity against cells presenting the HA-1 peptide.
03
Biological functions
Immune responseT cell activationAntigen presentation
04
Disease associations
Graft-versus-host disease (GVHD)Graft-versus-leukemia (GVL)Hematologic malignancies
05
Safety considerations
Potential for GVHDOn-target, off-tumor toxicity in hematopoietic cells
06
Biomarkers
HA-1 allele status in donor and recipientHLA-A*02:01
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