miR-17-92 cluster host gene (MIR17HG)

The miR-17-92 cluster host gene (MIR17HG) encodes a long non-coding RNA serving as the primary transcript for the polycistronic miR-17-92 cluster, located on chromosome 13q31.3. This gene produces a precursor that is processed into at least six microRNAs—miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1—which collectively regulate the expression of hundreds of protein-coding genes. These microRNAs play critical roles in numerous cellular processes, including the control of cell proliferation, differentiation, apoptosis, and organismal development (notably of the skeleton, heart, kidney, lung, and nervous system)[1][2][3][4]. Dysregulation or amplification of this locus is strongly associated with hematological and various solid cancers, where it acts as a potent oncogenic driver. The cluster also modulates key signaling pathways such as TGF-β and interacts with transcription factors including MYC and E2F family members. Because of these central roles, MIR17HG and its microRNAs are considered promising therapeutic targets and biomarkers in oncology, especially in colorectal and lung cancers, though direct drugs remain largely experimental as of 2025[5][6][7][8].

Other names

Putative microRNA 17 host gene proteinC13orf25MIRH1MIRHG1FLJ14178MIHG1NCRNA00048miR-17-92LINC00048long intergenic non-protein coding RNA 48non-protein coding RNA 48microRNA host gene (non-protein coding) 1microRNA host gene 1 (non-protein coding)mir-17-92 microRNA cluster

Inhibitors lower MIR17HG or miR-17-92 cluster activity, thereby increasing tumor-suppressor gene expression and/or reducing oncogenic signaling; may affect TGF-β pathway, PTEN, E2F, NF-κB, and others[5][7]