miR-17-92 microRNA primary transcript (pri-miR-17-92)

The **pri-miR-17-92** transcript is a long, polycistronic primary microRNA (pri-miRNA) that serves as the precursor for the miR-17-92 cluster, a group of six processed microRNAs (miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1) encoded within the MIR17HG gene[1][2][4]. After being transcribed, the ~800 nucleotide RNA adopts a distinct tertiary structure that determines how individual miRNA precursors within the transcript are processed into mature microRNAs[1][2][3][4]. These mature miRNAs play crucial roles in regulating cell cycle, proliferation, apoptosis, and development. Dysregulation of the miR-17-92 cluster is linked to cancer, cardiovascular disorders, neurodevelopmental disease, and aging, with overexpression particularly associated with oncogenesis[4][5]. Germline deletions of MIR17HG cause syndromic developmental defects in humans and mice[1]. The primary transcript is regulated at both the transcriptional and post-transcriptional level, including modulation by RNA-binding proteins such as hnRNP A1 and splicing factors such as SRSF3[1][6]. Importantly, **pri-miR-17-92 itself is a non-coding precursor molecule and not a direct therapeutic target; rather, the mature microRNAs derived from it, or the processes regulating its biogenesis, are potential intervention points[5].**

Other names

pri-miR-17-92amiR-17~92 primary transcriptMIR17HG primary transcriptmiR-17-92 cluster primary transcript