MiR-17-92a-1 cluster host gene (MIR17HG)

MiR-17-92a-1 cluster host gene (MIR17HG) is a long non-coding RNA (lncRNA) that serves as the primary transcript for the miR-17-92 cluster, a potent oncogenic microRNA group often called Oncomir-1 (HGNC: 23564). This cluster encodes six mature microRNAs—miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92a-1—which collectively regulate essential cellular processes such as proliferation, survival, and angiogenesis (NCBI Gene: 407975). MIR17HG is frequently overexpressed or amplified in numerous cancers, including B-cell lymphomas, multiple myeloma, and various solid tumors, where it promotes oncogenesis by silencing tumor suppressors like PTEN and BIM (NIH, 2023). In addition to its role as a miRNA precursor, MIR17HG-derived lncRNAs like lnc-17-92 (also known as RROL) act as chromatin scaffolds that facilitate the recruitment of transcription factors like c-MYC to metabolic gene promoters, driving lipogenesis and tumor growth (Morelli et al., 2022). Therapeutic development is focused on antisense oligonucleotides and microRNA inhibitors, with agents like RGLS4326 and RGLS8429 undergoing clinical evaluation for autosomal dominant polycystic kidney disease (Regulus Therapeutics, 2023). However, targeting this gene presents significant challenges due to its critical role in normal development, as evidenced by the fact that germline mutations cause Feingold syndrome type 2 (MedlinePlus, 2018).

Other names

MiR-17-92a-1 cluster host geneMIRH1NCRNA00048LINC00048C13orf25MIRHG1MIHG1Oncomir-1lnc-17-92RROLRNA regulator of lipogenesis

MIR17HG functions primarily as a precursor for the miR-17-92 cluster, which suppresses tumor suppressors such as PTEN, BIM, and CDKN1A to activate PI3K/AKT and NF-κB signaling (NIH, 2023). Additionally, MIR17HG-derived lncRNAs like lnc-17-92 act as chromatin scaffolds to promote c-MYC-mediated transcription of metabolic genes, such as ACACA, driving de novo lipogenesis (Morelli et al., 2022).