miR-181a1-regulated mRNA transcripts (miR-181a1 targets)

miR-181a1-regulated mRNA transcripts refer to the collective set of messenger RNA molecules whose expression and stability are controlled by the microRNA miR-181a-1. As a key post-transcriptional regulator, miR-181a-1 binds to the 3' untranslated regions (UTRs) of these transcripts, typically leading to their degradation or translational repression. This regulatory network is essential for various biological processes, including T-cell development, cell cycle progression, and apoptosis, by targeting critical genes such as PTEN, BCL2, and BAX. In many cancers, the dysregulation of these transcripts contributes to tumor growth, metastasis, and the development of chemoresistance to drugs like doxorubicin and cisplatin. Beyond oncology, these transcripts play significant roles in neurodegenerative diseases like Alzheimer's and Parkinson's by modulating mitochondrial function and neuronal survival. Therapeutic interventions targeting this system include miRNA mimics to restore tumor-suppressive functions or antagomirs to block oncogenic activity, thereby indirectly modulating the entire transcriptomic profile regulated by miR-181a-1.

Other names

miR-181a-1 targetsmiR-181a-5p targetsmiR-181a-3p targetsmiR-181a-regulated geneshsa-miR-181a-1 targetsMIR181A1 targets

MicroRNA-mediated gene silencing via mRNA degradation and translational inhibition