miR-29b binding site on progranulin mRNA (null)

The miR-29b binding site on progranulin mRNA (GRN mRNA) is an evolutionarily conserved sequence located in the 3′ untranslated region (3′UTR) of the GRN transcript. This site serves as a docking region for microRNA-29b (miR-29b), a small non-coding RNA that downregulates GRN by binding to this specific 3′UTR sequence, thereby repressing translation or destabilizing the transcript. Disruption of this interaction by targeted antisense oligonucleotides can relieve miR-29b-mediated silencing and increase progranulin protein production, offering a potential therapeutic approach for conditions associated with progranulin deficiency such as frontotemporal dementia. The site itself is not a protein or classic receptor but rather an RNA regulatory element that mediates a critical step in the post-transcriptional control of gene expression[1][3][4][5].

Other names

miR-29b site on GRN mRNAmicroRNA-29b binding site on progranulin mRNAmiR-29b regulatory site in GRN 3′UTR

Antisense oligonucleotides bind to the miR-29b binding site on GRN mRNA, preventing miR-29b from downregulating GRN and thus increasing progranulin protein translation[3][4][5] - This post-transcriptional interference relieves the suppression normally imposed by miR-29b on GRN mRNA[1]