miR-34a-regulated messenger RNAs

miR-34a target mRNAs are the transcripts whose expression is suppressed by microRNA-34a, a master tumor suppressor and regulator of cell fate. miR-34a binds a complementary sequence in the 3'-UTR of hundreds of mRNAs—including proto-oncogenes (e.g., MYC, MET, CDK4/6, BCL2, SIRT1), differentiation factors, and senescence regulators—causing their degradation or silencing[1][2][3][5][7]. The tumor suppressive effect of miR-34a is largely due to its ability to simultaneously downregulate multiple genes involved in cell proliferation, apoptosis resistance, invasion, metastasis, stemness, and immune escape, making it a focus of diagnostic and therapeutic research in cancer and fibrosis[1][2][5][8]. Therapeutic strategies often aim at modulating miR-34a itself; the diverse downstream mRNA targets represent the molecular endpoints affected by such intervention, rather than actionable drug targets themselves. A canonical target for therapeutic intervention would be miR-34a (microRNA-34a), not "miR-34a target mRNAs"[1][2][5]. The listed mRNAs are highly context-dependent, and the set may vary based on species, cell type, and disease context[7][8].

Other names

miR-34a-regulated mRNAsmiR-34a target genesmiR-34a direct targets

Post-transcriptional silencing by miR-34a binding to mRNA 3'-UTR, resulting in mRNA degradation or translational repression