mir-99a-let-7c cluster host gene (MIR99AHG)

MIR99AHG (mir-99a-let-7c cluster host gene) is a long noncoding RNA that acts as the host gene for the microRNA cluster miR-99a/let-7c/miR-125b2[1][4][5]. It is implicated in several regulatory processes, especially in cancer biology, where it can function as either a tumor suppressor (e.g., in lung adenocarcinoma by promoting autophagy and suppressing proliferation and metastasis) or a pro-metastatic factor (e.g., in colorectal cancer via alternative splicing). MIR99AHG exerts its effects through both its lncRNA transcript (interacting with proteins like ANXA2 and PTBP1 to modulate autophagy and splicing) and its encoded miRNAs that regulate key targets such as mTOR[2][3][5]. In immune response, its altered expression affects macrophage polarization and inflammation in the context of tuberculosis[1]. MIR99AHG and its associated miRNAs are frequently downregulated in cancers (often due to chromosomal deletions), and their expression correlates with patient prognosis, suggesting utility as biomarkers. While currently there are no direct drugs or safety concerns identified, MIR99AHG represents a potential therapeutic and diagnostic target, particularly for tumors with known dysregulation of this pathway[4][5].

Other names

MONCDILA1Megakaryocytic oncogenic non-coding RNACyclin D1-interacting long noncoding RNA 1C21orf34C21orf35LINC00478Long intergenic non-protein coding RNA 478

Potentially, modulation of gene expression via microRNA cluster activity Regulation of downstream targets (e.g., mTOR signaling, alternative splicing of SMARCA1 via PTBP1)