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Target intelligence / Profile preview
MIR1-1 host gene (MIR1-1HG)
- Target
- MIR1-1HG
- Molecular classification
- Non-coding RNA gene, MicroRNA host gene, Other
01
Overview
MIR1-1 host gene (MIR1-1HG) is a non-coding RNA gene and genomic locus encoding primary transcripts that are processed into muscle- and heart-specific microRNAs, specifically miR-1-1 and miR-133a-2. These microRNAs are pivotal regulators of cardiac and skeletal muscle differentiation, development, and pathology. The host gene itself does not encode a protein nor does it function as a classical therapeutic target, but its regulation is essential for proper expression of the embedded microRNAs. Disease relevance is indirect, reflecting the role of its microRNAs in cardiovascular and muscle biology. MIR1-1HG shares synonyms with related host genes, but should not be confused with functional proteins or direct drug targets.
- Other names
- MIR1-1HGMIR133A2HGC20orf166dJ353C17.1MIR1-1 host gene protein (misleading; not a protein)MIR133A2 host geneUncharacterized protein C20orf166 (misleading; not a protein)
02
Mechanism of action
Not applicable (The host gene locus is not a direct therapeutic target.)
03
Biological functions
Host locus for miR-1-1 and miR-133a-2Regulation of cardiac and skeletal muscle development and differentiation (via the microRNAs it encodes)Modulation of gene expression via the action of miR-1-1 and miR-133a-2
04
Disease associations
Cardiovascular disease (indirectly, via the function of miR-1-1 in heart development and pathology)Other (implicated in muscle disorders due to its role in differentiation pathways via microRNAs)
05
Safety considerations
None directly for MIR1-1HG; safety challenges for modulation relate to off-target effects of miRNA therapeutics affecting broader gene regulation
06
Biomarkers
miR-1-1 and miR-133a-2 levels
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