MIR137 host gene (non-protein coding) (MIR137HG)

MIR137 host gene (MIR137HG) is a large, non-protein-coding RNA gene located on chromosome 1, serving as the host gene for the microRNA miR-137[3]. MIR137HG itself does not code for a protein but is important as the primary transcript from which miR-137 is processed. Expression and regulation of MIR137HG directly affect the levels of mature miR-137, which plays critical roles in neuronal differentiation, brain development, synaptic function, and acts as a tumor suppressor in various cancers[1][3][4]. Dysregulation or epigenetic silencing (e.g., via CpG methylation) of MIR137HG can lead to reduced levels of miR-137 and is implicated in neuropsychiatric disorders such as schizophrenia and several types of cancer[3][4]. MIR137HG is not considered a direct therapeutic target itself (such as a receptor or enzyme), but its product, miR-137, is being explored for its role in disease pathways and as a biomarker or therapeutic target in neuropsychiatric and oncological conditions[3][4].

Other names

MIR137HGmiR-137 host geneMIR137 host gene (non-protein coding)AK094607