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Target intelligence / Profile preview
MIR181A1 host gene (MIR181A1HG)
- Target
- MIR181A1HG
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
MIR181A1 host gene (MIR181A1HG) is a long non-coding RNA gene located on chromosome 1. It is part of the regulatory network involving microRNA precursors, specifically mir-181, and is implicated in the control of multiple cellular processes including cell proliferation, cell death, extracellular matrix organization, bone development, and signaling pathways such as ERK and MAPK. MIR181A1HG has been associated with acute myeloid leukemia and other hematologic malignancies. Knockdown studies indicate that MIR181A1HG modulates the expression of hundreds of protein-coding genes involved in these biological pathways, suggesting a role in cancer biology and possibly serving as a biomarker for disease[3][9][8].
- Other names
- familial acute myelogenous leukemia related factorMIR181A1 host gene
02
Biological functions
Regulation of cell proliferationRegulation of cell deathRegulation of ERK and MAPK signalingCollagen fibril and extracellular matrix organizationBone development and ossification
03
Disease associations
Cancer (primarily acute myeloid leukemia)Acute myeloid leukemia with maturationOther hematologic malignancies (thrombocythemia, polycythemia vera, acute leukemia)
04
Biomarkers
Possible roles as a biomarker for acute myeloid leukemia and related blood disorders, based on disease-association studies and gene variant analysis
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