MIR1915 host gene (MIR1915HG)

MIR1915 host gene (MIR1915HG) encodes a long non-coding RNA (lncRNA) that functions as the host gene for microRNA-1915 (miR-1915)[3][4]. It is also known by the gene symbols C10orf114 and CASC10. The lncRNA itself does not encode a functional protein but instead acts through its RNA products, particularly via hosting the miR-1915 microRNA. MIR1915HG is located on human chromosome 10 and is classified among non-coding RNA genes[3][4]. The mature microRNA derived from this host gene, miR-1915-3p, has been shown to be dysregulated in several cancers—including colorectal cancer, breast cancer, lung cancer, and thyroid cancer—where it is variably described as having tumor suppressor or oncogenic roles depending on cancer context[1]. Current research recommends miR-1915-3p and, by implication, its host gene, as a candidate biomarker for cancer diagnosis and a potential subject for future therapeutic targeting[1]. However, there are no known direct drug interactions or established clinical safety concerns related to MIR1915HG itself.

Other names

MIR1915HGC10orf114CASC10bA418C1.3cancer susceptibility 10 proteincancer susceptibility candidate 10cancer susceptibility candidate gene 10MIR1915 host gene protein