MIR200C and MIR141 host gene (MIR200CHG)

The MIR200C and MIR141 host gene (MIR200CHG) is a non-coding RNA gene locus that gives rise to the microRNAs miR-200c and miR-141. This locus forms the miR-200c/miR-141 intergenic cluster on chromosome 12, spanning regions crucial for epithelial cell identity, epithelial-mesenchymal transition (EMT), stress response, and tumorigenesis. The primary transcript undergoes complex regulation involving DNA looping and transcriptional co-regulation with the nearby PTPN6 gene (SHP1), affecting cellular response to oxidative stress and tumorigenic stimuli[2][1]. Deregulation of miR-200c/miR-141 expression influences cancer progression, metastasis, chemosensitivity, and tissue development. While this locus itself is not a direct therapeutic target, the mature miRNAs it hosts are functional regulators with disease significance and therapeutic interest[1][2][4].

Other names

MIR200CHGMIR200C/141 host geneU47924.27MIR200C-141 genomic clustermiR-200c/miR-141 host locus

Not applicable for MIR200CHG itself; for miR-200c/miR-141, mechanisms include modulation of gene expression by binding target mRNAs and repressing translation (microRNA-mediated silencing)