MIR3142 host gene (MIR3142HG)

MIR3142 host gene (MIR3142HG) is a long intergenic non-coding RNA located on chromosome 5q33.3, generally described as the host gene for microRNAs miR-3142 and miR-146a[1][3][4][5]. While originally annotated for miR-3142, functional research indicates its predominant activity is the generation of miR-146a, a microRNA widely recognized as a negative regulator of the inflammatory response[3][4]. MIR3142HG expression is highly inducible by pro-inflammatory cytokines such as IL-1β, where it modulates the release of key inflammatory mediators (IL-8, CCL2) in fibroblasts via NF-kB signaling[3][4][5]. Differential expression and genetic variants in MIR3142HG are implicated in susceptibility to inflammatory and degenerative diseases, including IPF, acute lung injury, lumbar disc degeneration, and glioma[5]. Although not a traditional drug target, MIR3142HG serves as a critical non-coding regulatory element in inflammation and immune response networks, mainly through miR-146a-dependent mechanisms.

Other names

MIR3142 host geneMIR3142HGMIR146A host geneMIR3142HG (as commonly formatted)Host gene for miR-146a and miR-3142

Not applicable. Effects are mediated via the microRNAs (primarily miR-146a) produced from MIR3142HG, which can downregulate elements such as IRAK1 and TRAF6 in immune signaling networks[3].