MIR34B and MIR34C host gene (MIR34BHG)

MIR34BHG, also known as the MIR34B and MIR34C host gene, is a long non-coding RNA (lncRNA) transcribed adjacent to the microRNA miR-34b/c cluster. It is also called SPARCLE (suicidal PARP-1 cleavage enhancer). MIR34BHG/SPARCLE is induced by p53 after DNA damage and functions to enhance apoptosis by acting as a cofactor for caspase-3–mediated cleavage of PARP-1, a protein critical for DNA repair. By facilitating PARP-1 cleavage, MIR34BHG disrupts DNA-damage repair processes and promotes cell death in response to genotoxic stress. This activity is essential for effective p53-mediated tumor suppression and apoptosis. The gene is classified as a lncRNA and lacks a protein-coding function. Current data does not designate MIR34BHG as a traditional drug target or receptor, and there are no known direct interacting drugs or established clinical indications beyond its emerging role in apoptosis and potential links to cancer biology[1][2][3].

Other names

SPARCLEsuicidal PARP-1 cleavage enhancer

Enhances p53-induced apoptosis by promoting caspase-3–dependent PARP-1 cleavage, leading to inhibition of DNA repair and increased cell death after genotoxic stress