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MIR3667 host gene (MIR3667HG)
- Target
- MIR3667HG
- Molecular classification
- Long non-coding RNA (lncRNA), Non-coding RNA gene
01
Overview
MIR3667 host gene (MIR3667HG) is a long non-coding RNA (lncRNA) locus located on human chromosome 22. Its primary biological role is to serve as the transcriptional host for microRNA 3667 (MIR3667), meaning that the lncRNA transcript is processed to generate the embedded mature microRNA. The host gene itself is not protein coding and no independent biological function, apart from hosting the microRNA, has been described. While certain genetic studies have noted associations between alterations at this locus and specific diseases such as gallbladder cancer, these linkages are not well established. The host gene itself is not a therapeutic target, nor is it currently implicated directly in disease mechanisms or targeted by pharmacological agents[1][3][4].
- Other names
- C22orf34ENSG00000188511348645
02
Biological functions
Acts as the primary transcript (host transcript) for microRNA MIR3667No additional biological functions described for the lncRNA host gene itself
03
Disease associations
Genetic associations reported with gallbladder cancerImmunodeficiency-centromeric instability-facial anomalies syndrome 1
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