MIR3936 host gene (MIR3936HG)

MIR3936 host gene (MIR3936HG), also known as SLC22A5-AS1, is a long non-coding RNA (lncRNA) that serves as the host gene for the microRNA miR-3936 and functions as an antisense transcript to neighboring genes SLC22A5 and SLC22A4[1]. It is not a classical therapeutic target like a receptor or enzyme but is of increasing interest in molecular oncology. This lncRNA functions as a regulatory molecule, particularly by acting as a competitive endogenous RNA (ceRNA). In non-small cell lung cancer, SLC22A5-AS1 is upregulated and promotes oncogenic behaviors by sponging miR-195-5p, relieving the miRNA's repression of ITGA2, and thereby promoting cell proliferation, migration, and invasion[2]. Silencing SLC22A5-AS1 can suppress tumor growth and increase apoptosis, making it a candidate biomarker for disease progression and prognosis in certain cancers. However, there is currently little evidence of direct drug targeting or established therapeutic safety concerns for MIR3936HG[1][2]. MIR3936HG is not a receptor, enzyme, transporter, or classical therapeutic target, but rather a non-coding RNA gene implicated in gene expression regulation, especially in cancer biology. There is some inconsistency in the labels across sources, and the provided aliases occasionally refer to overlapping but not identical long non-coding RNAs (e.g., SLC22A5-AS1 and SLC25A25-AS1 appear in different contexts). For this entry, only confirmed aliases from authoritative databases are included[1]. No drugs or direct pharmacological interventions specifically target this lncRNA at present.

Other names

LOC553103SLC22A5-AS1SLC22A5 and SLC22A4 antisense RNA 1

Acts as a competitive endogenous RNA (ceRNA), particularly by sponging miRNAs such as miR-195-5p, which impacts expression of targets like ITGA2 (integrin α2) in cancer