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Target intelligence / Profile preview
MIR4453 host gene (MIR4453HG)
- Target
- MIR4453HG
- Molecular classification
- Long non-coding RNA (lncRNA), MicroRNA host gene (miRNA host gene)
01
Overview
MIR4453 host gene (MIR4453HG) is a long non-coding RNA (lncRNA) gene located on chromosome 4, also known by aliases DKFZP434I0714 and LINC02486[1][2][4]. As a member of the lncRNA and miRNA host gene classes, its primary known feature is to host the MIR4453 microRNA within its sequence, potentially functioning in the regulation of gene expression at the post-transcriptional level. There is an association reported between MIR4453HG and chronic kidney disease, but evidence for other direct biological or disease functions is limited. It is not currently considered a therapeutic target, nor are there any approved drugs or known biomarkers related to its clinical manipulation[2].
- Other names
- DKFZP434I0714LINC02486long intergenic non-protein coding RNA 2486MIR4453HG
02
Mechanism of action
Not applicable (no known therapeutics target this lncRNA directly)
03
Biological functions
Regulation of gene expressionHosts MIR4453 microRNA (potential for post-transcriptional regulation)Possibly involved in RNA processing (general to lncRNAs/miRNA host genes, specific functions uncharacterized for this gene)
04
Disease associations
Chronic kidney disease (association reported)Potential for other diseases (e.g., cancer), but no direct evidence for MIR4453HG specifically
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