MIR4500 host gene (non-protein coding) (MIR4500HG)

MIR4500 host gene (MIR4500HG) is a long non-coding RNA gene that contains the miRNA miR-4500 within its introns [1]. Its primary known biological role is to serve as the primary transcript (host) for miR-4500, a microRNA that acts as a tumor suppressor by inhibiting cell proliferation, migration, and invasion in a variety of cancers, including colorectal cancer [1]. miR-4500 achieves this by targeting oncogenes such as HMGA2, with MIR4500HG displaying promoter hypermethylation and silencing in tumors, leading to loss of miR-4500 function [1]. Like other lnc-pri-miRNA genes, MIR4500HG may also possess enhancer-like regulatory functions independent of its role as a miRNA host, though these non-canonical functions are suggested primarily through analogy with other similar lncRNA genes and are not yet specifically established for MIR4500HG [4]. MIR4500HG is a non-protein coding gene and is not considered an enzyme, receptor, or pharmacologic target molecule in the conventional sense. There are no recognized small molecules or drugs that interact directly with MIR4500HG, but its downregulation is being explored as a biomarker and potential diagnostic tool in oncology [1].

Other names

MIR4500 host gene (non-protein coding)hCG_1818123MIR4500HG

null (no drugs directly target this RNA gene; therapeutics could hypothetically aim to modulate miR-4500 expression)