Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mistletoe Lectin I (ML-I)
- Target
- ML-I
- Molecular classification
- Lectins, Ribosome-inactivating protein, Glycoprotein
01
Overview
Mistletoe Lectin I (ML-I) is a heterodimeric protein found in extracts from the European mistletoe plant (*Viscum album*). It consists of a toxic A chain that inhibits protein synthesis by irreversibly inactivating ribosomes, and a B chain that binds to galactose residues on cell surfaces, facilitating cellular uptake and mediating immunomodulatory effects. ML-I is a key component of mistletoe extracts used in complementary cancer therapy and is under investigation for its potential anticancer and immunomodulatory properties.
- Other names
- Viscum album Lectin IML1Mistletoe LectinViscum Lectin
02
Mechanism of action
The A chain inhibits ribosomal protein synthesis by depurinating rRNA. The B chain binds to galactose residues on cell surfaces, facilitating cellular uptake and triggering immunomodulatory effects.
03
Biological functions
CytotoxicityImmunomodulationCell adhesionRibosome inactivationProtein synthesis inhibition
04
Disease associations
CancerImmunodeficiencyInflammation
05
Safety considerations
Injection site reactionsFeverAllergic reactionsPotential for immunostimulation leading to autoimmunityVariable potency and composition of mistletoe extractsLack of standardized dosing
06
Interacting drugs
None (Mistletoe extracts are used, but specific drugs directly targeting ML-I are not well-defined)
07
Biomarkers
ML-I serum levels (as a measure of exposure)Immune cell activity (e.g., NK cell activity, lymphocyte proliferation)
Beyond the preview
Go deeper on Mistletoe Lectin I (ML-I).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mistletoe Lectin I (ML-I).