Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42)

SLC25A42 (Mitochondrial coenzyme A transporter SLC25A42) is a member of the solute carrier family 25, residing in the inner mitochondrial membrane. It catalyzes the exchange of coenzyme A (CoA) from the cytosol into the mitochondrial matrix, in exchange for (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate, thus supporting mitochondrial metabolic processes involved in fatty acid oxidation, energy production, and other biosynthetic reactions[2][6]. This transporter has been shown to play a crucial role in regulating cell metabolism and mitochondrial energy status. Notably, in cancer—particularly gastric cancer—SLC25A42 is upregulated, promotes tumor cell proliferation, and enables cancer cells to resist ferroptosis (a lipid peroxidation-driven form of cell death) by sustaining fatty acid oxidation and mitochondrial function[4]. Its expression correlates with poor prognosis in gastric cancer patients, making it a potential oncogenic factor and an investigational therapeutic target in oncology[4].

Other names

MGC26694Mitochondrial coenzyme A transporterSolute carrier family 25 member 42MECREN

Experimental inhibition or knockdown of SLC25A42 increases cellular susceptibility to ferroptosis, which can be rescued by ferroptosis inhibitors such as Fer-1, suggesting modulation of SLC25A42 can alter cell sensitivity to this programmed cell death pathway[4].