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Target intelligence / Profile preview
Mitochondrial Complex I (NADH Dehydrogenase) (Complex I)
- Target
- Complex I
- Molecular classification
- Enzyme, Oxidoreductase, Multi-subunit enzyme complex
01
Overview
Mitochondrial complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase, is the first and largest enzyme complex of the mitochondrial electron transport chain. It catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q10), coupled with proton translocation across the inner mitochondrial membrane. It plays a central role in cellular energy metabolism and its dysfunction is linked to various hereditary neurodegenerative diseases and metabolic disorders.
- Other names
- NADH:ubiquinone oxidoreductaseNADH dehydrogenaseRespiratory Complex I
02
Mechanism of action
Inhibition of electron transfer and/or proton pumping
03
Biological functions
Electron transportProton translocationOxidative phosphorylationATP synthesis
04
Disease associations
Neurodegenerative diseaseMetabolic disordersOxidative stressMitochondrial dysfunction
05
Safety considerations
Increased ROS production upon inhibitionImpaired cellular energy metabolism
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