Mitochondrial dicarboxylate carrier (SLC25A10)

The **mitochondrial dicarboxylate carrier (SLC25A10)** is an integral membrane transporter protein of the inner mitochondrial membrane encoded by the SLC25A10 gene[1][2][3]. It exchanges dicarboxylates such as malate, succinate, and malonate for phosphate, sulfate, and thiosulfate using an antiport mechanism, playing a central role in metabolite shuttling for the Krebs cycle, gluconeogenesis, urea synthesis, fatty acid metabolism, and sulfur metabolism[1][2][3]. SLC25A10 modulates lipid homeostasis in adipocytes and liver, influences insulin sensitivity, maintains cellular redox and energy homeostasis, and interacts with pathways critical in cancer and metabolic diseases[1][3]. Loss-of-function mutations can result in severe mitochondrial disease and neurodegenerative disorders, and the transporter is considered a therapeutic target in metabolic syndrome, cancer, and diabetes[1][2][3].

Other names

mitochondrial dicarboxylate carrierDICdicarboxylate ion carriersolute carrier family 25 member 10SLC25A10MTDPS19SLC25A10 proteindicarboxylate transporter

Competitive inhibition of dicarboxylate transport (by analogues); Inhibition increases sensitivity to oxidative stress and traditional anticancer drugs in tumors