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Target intelligence / Profile preview
Mitochondrial Electron Transport Chain Complex V (ATP synthase)
- Target
- ATP synthase
- Molecular classification
- Enzyme, ATP Synthase, Membrane Protein
01
Overview
Mitochondrial electron transport chain complex V, also known as ATP synthase or F1F0-ATP synthase, is the final enzyme complex in the mitochondrial electron transport chain. It is responsible for synthesizing adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate, utilizing the proton gradient generated by earlier complexes in the chain.
- Other names
- F1F0-ATP synthaseComplex V
02
Mechanism of action
Proton gradient-driven ATP synthesis
03
Biological functions
ATP synthesisOxidative phosphorylationProton transport
04
Disease associations
Mitochondrial complex V deficiencyNeurological impairmentCardiomyopathyMuscle weaknessDevelopmental delaysLactic acidosis
05
Safety considerations
Inhibition leads to severe energy depletionDysfunction causes severe metabolic disorders
06
Interacting drugs
Oligomycin (inhibitor)
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