Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitochondrial Electron Transport Complex II (Complex II)
- Target
- Complex II
- Molecular classification
- Enzyme, Oxidoreductase, Mitochondrial respiratory chain complex
01
Overview
Mitochondrial electron transport complex II (Complex II), also known as succinate dehydrogenase (SDH), is a key enzyme complex that links the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate and transfers electrons from succinate to ubiquinone, reducing it to ubiquinol. Unlike complexes I, III, and IV, complex II does not pump protons but provides reduced ubiquinol for downstream complexes. It is a heterotetramer composed of SDHA, SDHB, SDHC, and SDHD subunits. Mutations in complex II subunits are associated with mitochondrial diseases and certain cancers. Complex II also influences inflammation, hypoxia response, cell fate decisions, and metabolic control.
- Other names
- Succinate dehydrogenaseSDHSuccinate:ubiquinone oxidoreductaseEC 1.3.5.1
02
Mechanism of action
Inhibits succinate dehydrogenase activity, disrupting electron transport and ATP production.
03
Biological functions
Electron transportOxidation of succinate to fumarateReduction of ubiquinone to ubiquinolTricarboxylic acid (TCA) cycleOxidative phosphorylation
04
Disease associations
Mitochondrial diseaseCancerParagangliomaPheochromocytoma
05
Safety considerations
Inhibition can lead to mitochondrial dysfunctionPotential for off-target effects due to involvement in multiple cellular processes
06
Biomarkers
Succinate levelsFumarate levelsSDHA expressionSDHB expressionSDHC expressionSDHD expression
Beyond the preview
Go deeper on Mitochondrial Electron Transport Complex II (Complex II).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitochondrial Electron Transport Complex II (Complex II).