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Target intelligence / Profile preview
Mitochondrial elongation factor TUFM (TUFM)
- Target
- TUFM
- Molecular classification
- GTPase, Translation Elongation Factor, RNA binding protein
01
Overview
Mitochondrial elongation factor TUFM is a nuclear-encoded protein essential for mitochondrial protein synthesis. It facilitates the GTP-dependent binding of aminoacyl-tRNA to the ribosome A-site. Beyond translation, TUFM regulates programmed cell death pathways and is implicated in viral infection response and cancer. It is considered a potential therapeutic target due to its diverse roles.
- Other names
- COXPD4EF-TuMTEFTUP43
02
Mechanism of action
Inhibiting TUFM's GTPase activity or tRNA binding to disrupt mitochondrial translation and/or affect cell death pathways.
03
Biological functions
Mitochondrial protein synthesisTranslation elongationGTP bindingRegulation of autophagyRegulation of apoptosisRegulation of necroptosisRegulation of pyroptosis
04
Disease associations
Mitochondrial diseasesCancerViral infection
05
Safety considerations
Disruption of mitochondrial functionPotential off-target effects on bacterial EF-Tu (if targeting bacterial infections)
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