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Mitochondrial enolase superfamily member 1 (ENOSF1)
- Target
- ENOSF1
- Molecular classification
- Enzyme, Mitochondrial protein, Enolase superfamily
01
Overview
Mitochondrial enolase superfamily member 1 (ENOSF1) is a mitochondrial enzyme that catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate as part of the L-fucose catabolic pathway[2][10]. In addition to its enzymatic role, some splice variants of ENOSF1 act as natural antisense RNAs that can downregulate thymidylate synthase (TYMS) mRNA, affecting sensitivity to chemotherapeutic agents such as 5-fluorouracil[2][3]. ENOSF1 is linked to certain diseases, including cancer and dyskeratosis congenita, and is classified as a member of the enolase superfamily of enzymes[2][10].
- Other names
- Antisense RNA to thymidylate synthaseHSRTSBETAL-fuconate dehydrataseRTSTYMSASrTSFUCDmitochondrial enolase superfamily member 1rTSbeta
02
Mechanism of action
Downregulation of thymidylate synthase may enhance sensitivity to thymidylate synthase inhibitors such as 5-fluorouracil[3].
03
Biological functions
L-fucose catabolismMagnesium ion bindingL-fuconate dehydratase activityRegulation of thymidylate synthase expression
04
Disease associations
CancerDyskeratosis congenita
05
Safety considerations
Potential impact on nucleotide metabolism and nucleic acid synthesis; possible influence on response to chemotherapeutic agents targeting thymidylate synthase[3].
06
Interacting drugs
5-Fluorouracil
07
Biomarkers
Expression levels may correlate with sensitivity/resistance to thymidylate synthase inhibitors like 5-fluorouracil[3].
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