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Target intelligence / Profile preview
Mitochondrial fission regulator 1-like (MTFR1L)
- Target
- MTFR1L
- Molecular classification
- Other (outer mitochondrial membrane protein, regulatory protein)
01
Overview
Mitochondrial fission regulator 1-like (MTFR1L) is an outer mitochondrial membrane-localized protein required for the adaptation of mitochondrial morphology and dynamics in response to metabolic changes. It regulates mitochondrial shape, acting primarily as a negative regulator of mitochondrial fusion by controlling levels of the mitochondrial inner membrane fusion protein OPA1. MTFR1L is phosphorylated by AMP-activated protein kinase (AMPK), and this phosphorylation is essential for its function in mediating stress-induced mitochondrial fragmentation. Loss of MTFR1L results in mitochondrial elongation, increased mitochondrial interconnectivity, and cellular resistance to apoptosis, revealing its central role in the balance of mitochondrial fission and fusion in both mammalian cells and murine neurons[1][2][3][4].
- Other names
- FAM54BHYST1888MSTP116MST116Family with sequence similarity 54 member BProtein FAM54B
02
Biological functions
Regulation of mitochondrial morphologyAdaptation of mitochondrial dynamics to metabolic changesNegative regulation of mitochondrial fusionMediation of AMPK-dependent mitochondrial fragmentation
03
Disease associations
Other (not directly implicated as a primary target in major disease classes; potential for indirect relevance in metabolism, cell death, and stress responses)
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